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Yuan-Yuan Zhang, Ph.D

Post time:2017-12-13 Viewed:897

Yuan-Yuan Zhang, Ph.D
Associate Professor
Department of Pharmacology
West China School of Basic Medical Sciences & Forensic Medicine
Sichuan University
Room 24, 2/F, The Fifth Teaching Building
17 Renmin South Road 3rd Section   
West China College of Basic and Forensic Medicine   
Sichuan University, Chengdu, 610041, P. R. China
Work phone: +86-28-8550 1278
Mobile phone: +86-187 2849 5257
Education and training
  China Pharmaceutical University, Bachelor, Pharmaceutics, 2001
  Shanghai  Institutes  for  Biological  Sciences,  Chinese  Academy  of  Sciences,
Biochemistry and molecular biology, 2006
Dr.  Zhang  focus  on  the  tumor  microenvironment  and  molecular  mechanisms  of
anti-tumor effects of compounds extracted  from Traditional Chinese Medicines. She has got financial foundation from National National Science Foundation of China, and
Ph.D.  Programs  Foundation  of Ministry  of  Education  of  China.  She  has  published
dozens  of  academic  articles  in  SCI  journals.  She  also  published  a  book  as  the
editor-in-chief.  She  paid  a  lot  of  efforts  to  teaching  and  obtained  several  teaching
Area of interest
Gastrointestinal Cancer, autophagy, non-coding RNA, R&D of antineoplastic drugs
Selected Publications:
1.  Tian XT, Chen SJ, Zhang YY, Chen LY, Guo XZ, Xu Z, Liu H, Hu P, Chen ZY, Li ZX,
Huang CG. Absorption,  liver  first-pass  effect, pharmacokinetics  and  tissue distribution of
calycosin-7-O-β-D-glucopyranoside  (C7G)  and  its  major  active  metabolite,  calycosin,
following oral administration of C7G  in rats by HPLC-MS/MS. Journal of Pharmaceutical
and Biomedical Analysis 2018; 148: 350-354.
2.  Wu Y, Song Y, Xiong Y, Wang X, Xu K, Han B, Bai Y, Li L, Zhang Y (co-correspondence),
Zhou  L. MicroRNA-21  (Mir21)  promotes  cell  growth  and  invasion  by  repressing  tumor
suppressor PTEN in colorectal cancer. Cell Physiol Biochem 2017; 43(3): 945-958.
3.  Shi XW, Zhu HY*, Zhang YY, Zhou MM, Tang DL, Zhang HM. XuefuZhuyu decoction
protected  cardiomyocytes  against  hypoxia/  reoxygenation  injury  by  inhibiting  autophagy.
BMC Complementary and Alternative Medicine 2017; 17(1): 35.
4.  Xu K, Zhang YY (co-first author), Han B, Bai Y, Xiong Y, Song Y, Zhou LM. Suppression
subtractive  hybridization  identified  differentially  expressed  genes  in  colorectal  cancer:
microRNA-451a  as  a  novel  colorectal  cancer-related  gene.  Tumor  Biology  2017;  39(5):
1010428317705504. doi: 10.1177/1010428317705504.   
5.  Liao QJ, Zhang YY, Fan YC, Zheng MH, Bai Y, Eslick GD, He XX, Zhang SB, Xia HHX,
He  H.  Perception  of  Chinese  researchers  towards  academic  misconduct:  a  comparison
between  2015  and  2010.  Science  and  Engineering  Ethics  2017;  doi:
6.  Liu ZR, Song Y, Wan LH, Zhang YY* (co-correspondence), Zhou LM*. Over-expression
of miR-451a can enhance  the  sensitivity of breast cancer cells  to  tamoxifen by  regulating
14-3-3ζ,estrogen receptor α, and autophagy. Life Sciences 2016; 149: 104-13.
7.  Zhu  J, Chen X, Song Y, Zhang Y, Zhou L, Wan L. Deficit of RACK1 contributes  to  the
spatial memory impairment via upregulating BECLIN1 to induce autophagy. Life Sci. 2016;
151: 115-121   
8.  任为,牟宜双,许可,熊尧,张媛媛,周黎明*  ,邓文龙。迷迭香酸通过诱导凋亡及
抑制NF-kB 信号通路发挥抗肝癌作用的机制研究。《中药药理与临床》2016,32(2):31-35。
9.  Xiong  Y,  Zhang  YY,  Wu  YY,  Wang  XD,  Wan  LH,  Li  L,  Zhou  LM.  Correlation  of
over-expressions of miR-21  and Notch-1  in human  colorectal  cancer with  clinical  stages.
Life Sciences 2014; 106(1-2):19-24.  
10.  Xiong  Y,  Ma  XY,  Zhang  Z,  Shao  ZJ,  Zhang  YY,  Zhou  LM.  Apoptosis  induced  by
β,β-dimethylacrylshikonin  is associated with Bcl-2 and NF-κB  in human breast carcinoma
MCF-7 cells. Oncology Letters 2013; 6(6): 1789-93.
11.  Zhang YY, Li JN, Xia HHX, Zhang SL, Zhong J, Wu YY, Miao SK, Zhou LM. Protective
effects  of  losartan  in mice with  chronic  viral myocarditis  induced  by  coxsackievirus B3.
Life Sciences 2013; 92(24-26):1186-94.  
12.  Jin SJ, Ma XY, Zhang YY, Wan LH, Zhao Y, Zhou LM. Inhibitory Effects of Nobiletin on
Hepatocellular Carcinoma In Vitro and In Vivo. Phytotherapy Research 2014; 28(4): 560-7.
13.  Zhang YY, Zhou LM. Omentin-1, a new adipokine, promotes apoptosis through regulating
Sirt1-dependent  p53  deacetylation  in  hepatocellular  carcinoma  cells. European  Journal  of
Pharmacology 2013;698(1-3):137-44.   
14.  Shao ZJ, Zhang YY (co-first author), Fan YY, Jin SJ, Yan J, Zheng XW, Chen J, Xiong Y,
Zhou  LM.  β,β-Dimethylacrylshikonin  exerts  antitumor  activity  via  Notch-1  signaling
pathway in vitro and in vivo. Biochemical Pharmacology 2012; 84(4): 507-512.
15.  Zhang  YY,  Zhou  LM.  Sirt3  inhibits  hepatocellular  cell  growth  through  reducing
Mdm2-mediated p53 degradation. Biochemical and Biophysical Research Communications   
2012; 423 (1): 26-31.
16.  张媛媛,周黎明。药理学教学在以疾病为中心的医学培养模式中的探索。《中国药理
17.  Hu  ZP,  Yin  J,  Zhang  YY,  Jia  SY,  Chen  ZJ,  Zhong  J.  Characterization  of  the
immune  responses  elicited  by  baculovirus-based  vector  vaccines  against
influenza virus hemagglutinin. Acta Pharmcol Sin 2012; 33(6): 783-90.   
18.  Zhu  HY,  Huang  H,  Zhang  YY,  Chen  HS,  Wang  B,  Ye  G,  et  al.  Antiviral  effects  of
Yin-Zhi-Ku extract against human and duck hepatitis B virus replication. Asian Chemistry
Letters 2011; 5(4): 1-10.   
19.  Xia HH, Yang Y, Chu KM, Gu Q, Zhang YY, He H, Wong WM, Leung SY, Yuen ST, Yuen
MF, Chan AO, Wong BC.Serum macrophage migration-inhibitory factor as a diagnostic and
prognostic biomarker for gastric cancer. Cancer. 2009 Dec 1;115(23):5441-9.   
20.  ZhangYY, Xia HH, Zhuang ZH, Zhong J. “True” re-infection of Helicobacter pylori after
successful  eradication:  Worldwide  annual  rates,  risk  factors  and  clinical  implications.
Alimentary Pharmacology & Therapeutics 2009;29(2):145-60.   
21.  Zhu  HY,  Zhang  YY,  Ye  G,  Li  ZX,  Zhou  P,  Huang  CG.  In  vivo  and  in  vitro  antiviral
activities  of Calycosin-7-O-β-D-glucopyranoside  against  coxsackievirus B3. Biological & Pharmaceutical Bulletin 2009; 32(1): 68-73.   
22.  张媛媛,钟江。手足口病与肠道病毒 71型。《微生物与感染》,2008;3(2):97-99。  
23.     Zhang YY, Xia HH. Novel therapeutic approaches for hepatocellulcar carcinoma: fact and
fiction. World J Gastroenterology 2008 ;14(11):1641-2.
24.  Tang YH,  Zhang YY,  Zhu HY, Huang CG. A  high-performance  liquid  chromatographic
method for saikosaponin a quantification in rat plasma. Biomedical Chromatography 2007;
21(5): 458-462.   
25.  Zhang YY, Zhu HY, Ye G, Huang CG, Yang YZ, Chen RZ, Yu Y, Cui XL. Antiviral effects
of Sophoridine  against Coxsackievirus B3  and  its pharmacokinetics  in  rats. Life Sciences
2006; 78: 1998-2005.   
26.  Zhang YY, Zhu HY, Huang CG, Cui XL, Gao YJ, Huang Y, Gong WF, Zhao Y, Guo SS.
Astragaloside  IV  exerts  its  antivirus  effects  against  Coxsackievirus  B3  by  upregulating
IFN-γ. Journal of Cardiovascular Pharmacology 2006; 47(2): 190-197.   
27.  Tang YH, Zhu HY, Zhang YY, Huang CG. Determination of human plasma protein binding
of  baicalin  by  ultrafiltration  and  high-performance  liquid  chromatography.  Biomedical
Chromatography 2006; 20(10): 1116-1119.