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Xiaodong SUN

Post time:2017-12-13 Viewed:315

Xiaodong SUN

Associate Investigator
Department of Pharmacology,   
West China School of Basic Medical Sciences & Forensic Medicine,   
Sichuan University
Phone: 0086-18224464806
SUN  Xiaodong’s  current  research  interests  focus  on  understanding  the  cellular
metabolism and diseases and the pharmacological research of related drugs including
following  research  areas:  (1)  Intracellular  vesicle  fate  and  autophagy;  (2)
Cytoskeleton and  intracellular vesicle  trafficking; (3) Pharmacological mechanism of
cellular energy metabolism drugs
Sept.  2010  -  Jun.  2013:  Ph.D.  in  Cell  Biology,  College  of  Life  Sciences,  Nankai
University, China.   
Sept. 2007 - Jun. 2010: M.S. in Genetics, College of Life Sciences, Nankai University,
Sept.  2000  -  Jun.  2004:  B.S.  in  Biological  Technology,  College  of  Life  Sciences,
Nankai University, China.   
Mar. 2015 - now: Associate investigator at Sichuan University
Dec. 2013 - Dec. 2014: Postdoctoral fellow, Department of Biomedical Engineering at
Georgia Institute of Technology & Emory University School of Medicine.   
Jul. 2004 - Jun. 2010: Staff, College of Life Sciences, Nankai University, China.   
Sep. 2005, assistant tutor at Nankai University   
Dec 2009, instructor at Nankai University
(1) Medical Cell Biology
(2) Pharmacology
1) Sun Q*, Yong X* SunX*, Yang F*, Dai Z, Gong Y, Zhou L, Zhang X, Niu D, Dai
L,  Liu  J,  Jia  D.  (2017)  Structural  and  functional  insights  into  sorting  nexin  5/6
interaction with bacterial effector IncE. Signal Transduction and Targeted Therapy 2:
2) Yang Y*, Ran J*, Sun L*, Sun X*, Luo Y, Yan B, Tala, Liu M, Li D, Zhang L, Bao
G, Zhou, J. (2015) Cyld regulates noscapine activity in acute lymphoblastic leukemia
via a microtubule-dependent mechanism. Theranostics 5(7): 656-666.   
3) Tala*, Xie S*, Sun X*, Sun X, Ran J, Zhang L, Li D, Liu M, Bao G, Zhou J. (2014)
Microtubule-associated protein mdp3 promotes breast cancer growth and metastasis.
Theranostics 4(10): 1052-1061.   
4) Li D*, Sun X*, Zhang L, Yan B, Xie S, Liu R, Liu M, Zhou  J.  (2014) Histone
deacetylase  6  and  cytoplasmic  linker  protein  170  function  together  to  regulate  the
motility of pancreatic cancer cells. Protein & Cell. 5(3): 214-223.   
5) Liu M, Li D, Sun L, Chen J, Sun X, Zhang L, Huo L, Zhou J. (2014) Modulation of
Eg5  activity  contributes  to  mitotic  spindle  checkpoint  activation  and  Tat-mediated
apoptosis in CD4-positive T-lymphocytes. Journal of Pathology 233(2): 138-147.   
6) Sun L, Sun X, Xie S, Yu H, Zhong D. (2014) Significant decrease of ADP release
rate  underlies  the  potent  activity  of  dimethylenastron  to  inhibit mitotic  kinesin Eg5
and cancer cell proliferation. Biochemical  and biophysical  research communications
447(3): 465-470.   
7) Xie S, Dong B, Sun X, Tala, He X, Zhou J, Liu M, Li D. (2014) Identification of a
cytoplasmic linker protein as a potential target for neovascularization. Atherosclerosis
233(2): 403-409.   
8) Sun X*, Liu M*, Hao J*, Li D, Luo Y, Wang X, Yang Y, Li F, Shui W, Chen Q,
Zhou J. (2013) Parkin deficiency contributes to pancreatic tumorigenesis by inducing
spindle multipolarity and misorientation. Cell Cycle 12(7): 1133-1141.   
9) Sun X, Li F, Dong B, Suo S, Liu M, Li D, Zhou  J.  (2013) Regulation of  tumor
angiogenesis  by  the  microtubule-binding  protein  CLIP-170.  Protein  &  Cell  4(4):
10)  Zhang  C,  Sun  X,  Ren  Y,  Lou  Y,  Zhou  J,  Liu M,  Li  D.  (2012)  Validation  of
Polo-like kinase 1 as a therapeutic target in pancreatic cancer cells. Cancer Biology &
Therapy 13(12): 1214-1220.   
11) Sun X*, Li D*, Yang Y*, Ren Y, Li J, Wang Z, Dong B, Liu M, Zhou J. (2012)
Microtubule-binding protein CLIP-170 is a mediator of paclitaxel sensitivity. Journal
of Pathology 226(4): 666-673.   
12)  Peng G, Ren Y,  Sun X,  Zhou  J,  Li D.  (2012)  Inhibition  of  farnesyltransferase
reduces  angiogenesis  by  interrupting  endothelial  cell  migration.  Biochemical
Pharmacology 83(10): 1374-1382.   
13)  Li  J*,  Sun X*, Wang  Z, Chen  L,  Li D,  Zhou  J,  Liu M.  (2012) Regulation  of
vascular  endothelial  cell  polarization  and  migration  by  Hsp70/Hsp90-organizing
protein. PLoS One 7(4): e36389.   
14) Sun X D*, Shi X J*, Sun X O*, Luo Y G, Wu X J, Yao C F, Yu H Y, Li D W, Liu
M,Zhou  J.  (2011)  Dimethylenastron  suppresses  human  pancreatic  cancer  cell migration and  invasion  in vitro via allosteric  inhibition of mitotic kinesin Eg5. Acta
Pharmacologica Sinica 32(12): 1543-1548.   
15) Liu M, Aneja R, Sun X, Xie S, Wang H, Wu X, Dong J T, Li M, Joshi H C,Zhou J.
(2008)  Parkin  regulates  Eg5  expression  by  Hsp70  ubiquitination-dependent
inactivation of c-Jun NH2-terminal kinase. Journal of Biological Chemistry 283(51):