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Lihong Wan, M.D., Ph.D.

Post time:2017-12-13 Viewed:597

Lihong Wan, M.D., Ph.D.
Associate professor
Department of Pharmacology, West China School of Basic Medical Sciences &
Forensic Medicine
Sichuan University
Department of Pharmacology,
West China School of Basic Medical Sciences & Forensic Medicine,   
Sichuan University, Sichuan Province, Chengdu, 610041, P. R. China
Phone: 86-1388003280
Dr. Wan main research interests lie in the study of understanding the mechanism of
drug addiction, neurodegenerative disease and airway remodeling disease. The focus
of Dr. Wan’s research program is to define the role of RACK1 in drug addiction,
neurodegenerative disease and airway remodeling disease. The ongoing research
project is: The bidirectional regulation mechanism of RACK1 on bronchial epithelial
cell damage repair process of airway remodeling in asthma and the intervention
effect of macrolides. This project is supported by National Natural Science
Foundation of China. Dr. Wan has published 70 refereed papers, including 22 SCI
papers; 16 papers by the first author (correspondent) SCI.
 Lihong Wan, M.D., Ph.D.
Education and Training   
  West China University of Medical Sciences MD, Medicine 2000
  Sichuan University MS, Pharmacology 2005
  Sichuan University Ph.D, Chronobiology 2009
  Molecular biology medical center, Kantonsspital Aarau, Switherland, Visiting
scholar 2003
  NIH, Visiting scholar 2015
Area of Interest   
Drug addiction; Neurodegenerative disease; Asthma; Cell signal
Selected Publication
1. Wan L, Su L, Xie Y, Liu Y, Wang Y, Wang Z. Protein receptor for activated C kinase 1
is involved in morphine reward in mice. Neuroscience, 2009, 161(3): 734-42.   
2.  Wan Lihong, Wang Zhengrong, Zhou Liming.  Protecting Effects of Emodin on
Multiorgan Failure of Rats With Severe Acute Pancreatitis.  Pancreas, 2009, 38(7):
3.  Wan LH, Chen J, Li L, Xiong WB, Zhou LM. Protective effects of Carthamus
tinctorius injection on isoprenaline-induced myocardial injury in rats.  Pharm Biol,
2011, 49(11): 1204-1209.   
4. Wan L, Xie Y, Su L, Liu Y, Wang Y, Wang Z. RACK1 affects morphine reward via BDNF.
Brain Res, 2011, 1416: 26-34.   
5. Zhou Y, Tan X, Kuang W, Liu L,  Wan L
.  Erythromycin  ameliorates
cigarette-smoke–induced emphysema and inflammation in rats.  Transl Res, 2012,
159(6): 464-472.
6. Li LK, Kuang WJ, Huang YF, Xie HH, Chen G, Zhou QC, Wang BR,  Wan LH*
Anti-tumor effects of Astragalus on hepatocellular carcinoma in vivo.  Indian  J
Pharmacol, 2012, 44(1): 78-81.
7. Wu YYa
, Wan LHa
, Zheng XW, Shao ZJ, Chen J, Chen XJ, Liu LT, Kuang WJ, Tan XS,
Zhou  LM.  Inhibitory  Effects  of  β,β-Dimethylacrylshikonin on Hepatocellular
Carcinoma In Vitro and In Vivo. Phytother Res, 2012, 26(5):764-71.   
8. L. Wan, L. Liu, Z. Zhang, Y. Zhou, Y. Xiong, D. Li and L. Zhou. Low-dose azithromycin
attenuates OVA-induced airway remodeling and inflammation via down-regulating
TGF-β1 expression in rat. Euro J Inflam, 2013, 1(1): 133-145. Lihong Wan, M.D., Ph.D.
9.  Liu LT*
, Wan LH*
, Song XH, Xiong Y, Jin SJ, Zhou LM. Relevance of class 1 integrons
and  extended‑spectrum  β‑lactamases in drug‑resistant Escherichia coli. Mol Med
Rep, 2013, 8(4):1251-5.
10   Teng Y, Zhang MQ, Wang W, Liu LT, Zhou LM, Miao SK, Wan LH*
. Compound
danshen tablet ameliorated abeta25-35-induced spatial memory impairment in mice
via rescuing imbalance between cytokines and neurotrophins.  BMC Complement
Altern Med, 2014, 14(1): 23.
11 Li-Tao LIU, Jie-Jun ZHU, Li-Hong WAN*a
, Li-Ming ZHOU*a
12  Liu L, Zhu J, Zhou L,  Wan L
. Alcohol-induced reward
memory is positively associated with persistent high levels of RACK1, LC3-II/I and
synaptophysin in hippocampus of C57BL/6J mice.  J NEUROL SCI-TURK, 2015, 32(4):
13  Zhou Y, Liao S, Zhang Z, Wang B,  Wan L
. RACK1 promotes maintenance of
morphine-associated memory via activation of an ERK-CREB dependent pathway
in hippocampus. Sci Rep, 2016 Feb 2, 6: 20183.    
14  Zhu J, Chen X, Song Y, Zhang Y, Zhou L, Wan L
. Astragalus injection attenuates
bleomycin-induced pulmonary fibrosis via down-regulating Jagged1/Notch1 in
lungs. J Pharm Pharmacol, 2016 Mar; 68(3): 389-96.    
15  Zhu J, Liao S, Zhou L, Wan L
. Deficit of RACK1 contribute to the
spatial memory impairment via up regulating BECLIN1 to induce autophagy. Life
Sci, 2016 Apr 15; 151: 115-21.      
. Tanshinone  IIA attenuates Aβ25-35
16  Liu Y, Pu Y, Li D, Zhou L, Wan L*. Azithromycin ameliorates airway remodeling via
inhibiting airway epithelium apoptosis. Life Sci, 2017 Feb 1; 170: 1-8.    
-induced spatial
memory impairment via upregulating receptors for activated C kinase1 and
inhibiting autophagy in hippocampus.  J Pharm Pharmacol,  2017 Feb; 69(2):