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Li-ming Zhou, M.D., Ph.D.

Post time:2017-12-13 Viewed:524

Li-ming Zhou, M.D., Ph.D.   
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Professor   
Department of Pharmacology, West China School of Basic Medical
Sciences & Forensic Medicine Sichuan University   
Address   
Department of Pharmacology, West China School of Basic Medical
Sciences & Forensic Medicine   
Sichuan University, Sichuan Province, Chengdu, 610041, P. R. China
Phone: 86-13032896118
E-mail:zhou108@163.com
Sichuan University, Sichuan Province, Chengdu, 610041, P. R. China
Phone: 86-13032896118
E-mail:zhou108@163.com   
Dr. Zhou main research interests lie in the study of understanding
the molecular mechanism of cancer and cancer drugs. The focus of
Dr. Zhou’s research program is to define the role of microRNA-451a
in colorectal cancer and breast cancer. The ongoing research project
including 1) MiR-451a introduced ER-stress associated apoptosis in
colorectal cancer. 2) microRNA-451a is associated with ERα expression and response to tamoxifen in breast cancer. Dr. Zhou still
interesting in looking for useful content of Chinese medicine. Dr.
Zhou has published 61 refereed papers including 35 SCI papers and
12 book chapters. With her expertise, Dr. Zhou served as an
evaluation expert for China CFDA. Now she is the director of the
department of pharmacology at Sichuan University.
 
Education and Training   
 
  West China University of Medical Sciences MD, Medicine 1985   
1994
Pharmacology 2006
Harvard University, Boston, USA , Visiting Scholar, 1998   
The Scripps Research Institute, San Diego, USA , Visiting Scholar,
2000     
 
Area of Interest   
 
Molecular mechanism of colorectal cancer and breast cancer ,   
anticancer drug of Chinese medicine, Cell signal   
 
Selected Publication   
 
1.  Jian Chen , Litao Liu , Ruanling Hou , Zhenjun Shao , Yiying Wu,
Xiajing Chen Liming Zhou※
,Calycosin promotes proliferation of
estrogen receptor-positive cells via estrogen receptors and ERK1/2
activation in vitro and in vivo,Cancer Letters 2011, 308(2): 144–151
2.  Jianlei Zhaog, Jian Chen, Wenfu Tang, Lihong Wan, Wenbi Xiong   
and Liming Zhou※,Efect of Da-Cheng-Qi decoction on
pancreatitis-associated lung injury in patients and anti-infammatory
responses in rat models,Pharmaceutical Biology,2011, 49(10):
1058–1064.
3. Shao Zhen-Jun, Zheng Xiao-Wei, Feng Ting, Huang Juan, Chen Jian,
Wu Yi-Ying, Li-Ming Zhou*, Tu Wen-Wei, Li Hong. Andrographolide
exerted its antimicrobial effects by up-regulation of human
β-defensin-2 induced through p38 MAPK and NF-κB pathway in
human lung epithelial cells. Can J Physiol Pharmacol 2012 ; 84(4):507-512
4.  Wu YY, Wan LH, Zheng XW, Shao ZJ, Chen J, Liu LT, Kuang WJ, Tan
XS, Li-Ming Zhou*. Inhibitory effects of β,β-Dimethylacrylshikonin on
hepatocellular carcinoma in vitro and in vivo. Phytother Res 2012;
26(5):764-767
5.  Li-Hong Wan, Jian Chen, Liang Li, Wen-Bi Xiong, and Li-Ming
Zhou*, Protective effects of Carthamus tinctorius injection on
isoprenaline-induced myocardial injury in rats,Pharmaceutical
Biology, 2011; 49(11): 1204–1209
6.  Yuan-Yuan Zhang, Jin-Nan Li, Harry Hua-Xiang Xia, Shi-Lun Zhang,
Jiang Zhong, Yi-Ying Wu , Shi-Kun Miao , Li-Ming Zhou*,Protective
effects of losartan in mice with chronic viral myocarditis induced by
coxsackie virus B3. Life Sciences, 2013; 10(92) :1186–1194
7.  Yao Xiong, Xiu Ying Ma, Ziran Zhang, Zhen Jun Shao, Yuan Yuan
Zhang and Li-Ming Zhou*, Apoptosis induced by
β,β-dimethylacrylshikonin is associated with Bcl-2 and NF-κB in
human breast carcinoma MCF-7 cells. Oncology Letters 2013;6(6):
1789-1793   
8.  Li-Tao Liu, Li Hong Wan, Xiao Hong Song, Yao Xiong, Shao Ju Jin ,
Li-Ming Zhou*, Relevance of class 1 integrons and extended
spectrum β-lactamases in drug resistant Escherichia coli. Molecular
Medicine Reports, 2013; 8(4): 1251-1255,   
acetylation in hepatocellular carcinoma cells. European Journal of
Pharmacology, 2013,69: 8137–144
9.    Xiuying Ma, Shaoju Jin,    Yuanyuan Zhang,    Lihong Wan,   
Yanyan Zhao , Li-Ming Zhou* Inhibitory    Effects of Nobiletin on
Hepatocellular Carcinoma In Vitro and In Vivo    Phytother. Res. 2014;
28(4): 560–567
10   Shaoju Jin, Yishuang Mu, Xiaodong Wang, Zhenru Liu, Lihong
Wan, Yao Xiong, Yuanyuan Zhang, Li Li, Li-Ming Zhou*,  
Overexpressed RACK1 is positively correlated with malignant degree
of human colorectal carcinoma. Moleculor Biology Reports. 2014;
41(5):3393-3399.   
11. Yao Xiong, Yuan-Yuan Zhang, Yi-YingWu, Xiao-Dong Wang,
Li-Hong Wan, Li- Li , Li-Ming Zhou*, Correlation of over-expressions of miR-21 and Notch-1 in human colorectal cancer with clinical
stages, Life Sciences, 2014;106(1-2): 19–24
12.Wen-Bi Xiong, Zhen-Jun Shao†, Yao Xiong,  Jian Chen, Yun Sun,
Ling  Zhu  and  Li-Ming  Zhou*   Dehydroandrographolide  enhances
innate  immunity  of  intestinal  tract  through  up-regulation  the
expression  of  hBD-2,DARU  Journal  of  Pharmaceutical  Sciences,
2015;23(1):1-7
13.    Zhenru Liu, Baodong Ling, Li-Ming Zhou*,Prevalence of 16S
rRNA methylase, modifying enzyme, and extended-spectrum
beta-lactamase genes among Acinetobacter    baumannii isolates   
14. Zhen-Ru Liu , Yi Song, Li-Hong Wan, Yuan-Yuan Zhang , Li-Ming
Zhou*,Over-expression of miR-451a can enhance the sensitivity of
breast cancer cells to tamoxifen by regulating 14-3-3ζ, estrogen
receptor α,and autophagy,Life Sciences 2016;149(15):104-113
15   Yun Zeng, Liqin Wang, Zijian Zhou, Xiaoyong Wang, Yang Zhang,
Junqing Wang,c Peng Mi, Gang Liu and Li-Ming Zhou*, Gadolinium
hybrid iron oxide nanocomposites for dual T1- and T2-weighted MR
imaging of cell labeling Biomaterials Science,2017; 5(1), 50-56   
16   Ke Xu, Yuan-Yuan Zhang, Bin Han, Yang Bai, Yao Xiong,Yi Song   
and Li-Ming Zhou*, Suppression subtractive hybridizationidentified
differentially expressed genesin colorectal cancer: microRNA-451a
as a novel colorectal cancer related gene, Tumor Biology;2017:
1–9.   
17   Yiying Wu, Yi Song, Yao Xiong, Xiaodong Wang, Ke Xu, Bin Han
Yang Bai, Li Li, Yuanyuan Zhang,Li-Ming Zhou*, MicroRNA-21
(Mir-21) Promotes Cell Growth and Invasion by Repressing Tumor
Suppressor PTEN in Colorectal Cance,Cell Physiol Biochem
2017;43(3):945-958